Thionyl Chloride → 4-[chloro(2-methyl-5-phenylfuran-3-yl)methyl]tetrahydro-2H-pyran

HRID 1877037

반응식

HRID 1877037 반응식
[CH3:1][C:2]1[O:3][C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:5][C:6]=1[CH:7]([CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)O.S(Cl)([Cl:23])=O>C1(C)C=CC=CC=1>[Cl:23][CH:7]([C:6]1[CH:5]=[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[O:3][C:2]=1[CH3:1])[CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 68514112(2-methyl-5-phenylfuran-3-yl)(tetrahydro-2H-pyran-4-yl)methanol

생성물 1

HCID 685124234-[chloro(2-methyl-5-phenylfuran-3-yl)methyl]tetrahydro-2H-pyran수율 100%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a solution of (2-methyl-5-phenylfuran-3-yl) (tetrahydro-2H-pyran-4-yl)methanol (1.8 g) in toluene (20 mL) was added thionyl chloride (1.4 mL), and the mixture was stirred at room temperature overnight. The solvent was evaporated under reduced pressure to give the title compound (1.9 g, 100%) as an oil.

후처리

  1. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-0e72f28db2894c088dc58f41dc2592a1
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08309580B2

연결된 노트

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