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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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2-Chloro-4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenylethynyl}-benzoic acid → 2-Chloro-4-(2-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenyl}-ethyl)-benzoic acid

HRID 1877427
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HRID 1877427 반응식
[Cl:1][C:2]1[CH:10]=[C:9]([C:11]#[C:12][C:13]2[CH:18]=[C:17]([Cl:19])[C:16]([O:20][C:21]3[C:26]([C:27]([N:29]4[C:38]5[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=5)[N:32]([CH:39]5[CH2:41][CH2:40]5)[CH2:31][CH2:30]4)=[O:28])=[CH:25][CH:24]=[CH:23][N:22]=3)=[CH:15][C:14]=2[Cl:42])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]>C(O)C.[Pd]>[Cl:1][C:2]1[CH:10]=[C:9]([CH2:11][CH2:12][C:13]2[CH:18]=[C:17]([Cl:19])[C:16]([O:20][C:21]3[C:26]([C:27]([N:29]4[C:38]5[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=5)[N:32]([CH:39]5[CH2:41][CH2:40]5)[CH2:31][CH2:30]4)=[O:28])=[CH:25][CH:24]=[CH:23][N:22]=3)=[CH:15][C:14]=2[Cl:42])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 1

HCID 592945422-Chloro-4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenylethynyl}-benzoic acid

생성물 1

HCID 592945442-Chloro-4-(2-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenyl}-ethyl)-benzoic acid수율 100.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a suspension of 2-chloro-4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-2-yloxy]-phenylethynyl}-benzoic acid (100 mg, 0.16 mmol, 1.0 equiv; Example 168) in ethanol (1.5 mL) was added palladium on carbon (3.2 mg, 0.003 mmol, 0.02 equiv; 10% Pd/C; [CAS RN 7440-05-3]) and the reaction mixture stirred under an atmosphere of hydrogen (3 bar) at rt over night. Removal of the solvent mixture under reduced pressure, filtration over Celite® and lyophilization from dioxane provided 100 mg (96%) of the title compound as an off-white solid. MS (ISP): 620.3 [M−H]−.

후처리

  1. customRemoval of the solvent mixture
  2. filtrationunder reduced pressure, filtration over Celite® and lyophilization from dioxane

출처 및 근거

ORD 기록
ord-c8c60f253ea147ed8d8c384482e25099
출처 데이터셋
uspto-grants-2012_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08309734B2

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