m-Chlorophenylhydrazine hydrochloride → HCID 58345436, 화합물

HRID 1877981노트

반응식

HRID 1877981 반응식
[CH2:1]([O:3][C:4](=[O:20])[C:5](=O)[CH2:6][C:7]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([O:17][CH3:18])[CH:10]=1)=O)[CH3:2].Cl.[Cl:22][C:23]1[CH:24]=[C:25]([NH:29][NH2:30])[CH:26]=[CH:27][CH:28]=1>>[Cl:22][C:23]1[CH:24]=[C:25]([N:29]2[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[C:11]([O:17][CH3:18])[CH:10]=3)=[CH:6][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:20])=[N:30]2)[CH:26]=[CH:27][CH:28]=1

참가 물질

3

반응물 2

HCID 75331m-Chlorophenylhydrazine hydrochlorideHCID 43186887Ethyl 4-(3,4-dimethoxyphenyl)-2,4-dioxobutanoate

생성물 1

HCID 58345436HCID 58345436, 화합물수율 74%

실험 절차

Starting from 1 g (3.57 mmol) of 4-(3,4-dimethoxyphenyl)-2,4-dioxobutanoic acid ethyl ester from example 12A and 868.8 mg (4.85 mmol) of 3-chlorophenylhydrazine hydrochloride, 1.03 g (2.7 mmol, 74% yield of theory) of product are obtained according to the method described in example 4A and after purification by preparative HPLC.

후처리

  1. customare obtained
  2. customafter purification by preparative HPLC

출처 및 근거

ORD 기록
ord-8020358e08c04f1085f73136f4f21512
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314089B2

반응 노트

불러오는 중…