Potassium Hydroxide → HCID 58345413, 화합물

HRID 1877987노트

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=3)=[CH:11][C:10]([C:23]([O:25]CC)=[O:24])=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[OH-].[K+]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:12]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=3)=[CH:11][C:10]([C:23]([OH:25])=[O:24])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 14797Potassium Hydroxide

HCID 58345436HCID 58345436, 화합물

생성물 1

HCID 58345413HCID 58345413, 화합물수율 94%

실험 절차

Starting from 500 mg (1.29 mmol) of ethyl 1-(3-chlorophenyl)-5-(3,4-dimethoxy-phenyl)-1H-pyrazole-3-carboxylate from example 17A and 725.2 mg (12.9 mmol) of potassium hydroxide, 434.1 mg (1.2 mmol, 94% yield of theory) are obtained as crystals according to the method described in example 7A.

후처리

customare obtained as crystals

출처 및 근거

ORD 기록: ord-8289ba4f517548f7a9ac12a3ccba5dc3
출처 데이터셋: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08314089B2

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