홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Diisopropyl diazene-1,2-dicarboxylate → tert-Butyl 3-(2-(3-(5-bromopyrazin-2-ylamino)-1H-pyrazol-5-yl)-3-methoxyphenoxy)propylcarbamate

HRID 1878312
노트
인쇄 미리보기

반응식

HRID 1878312 반응식
N(C(OC(C)C)=O)=NC(OC(C)C)=O.[OH:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23].[Br:27][C:28]1[N:29]=[CH:30][C:31]([NH:34][C:35]2[CH:39]=[C:38]([C:40]3[C:45]([O:46][CH3:47])=[CH:44][CH:43]=[CH:42][C:41]=3O)[NH:37][N:36]=2)=[N:32][CH:33]=1>C1COCC1>[Br:27][C:28]1[N:29]=[CH:30][C:31]([NH:34][C:35]2[CH:39]=[C:38]([C:40]3[C:45]([O:46][CH3:47])=[CH:44][CH:43]=[CH:42][C:41]=3[O:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:23])([CH3:25])[CH3:24])[NH:37][N:36]=2)=[N:32][CH:33]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 3838134tert-butyl N-(3-hydroxypropyl)carbamateHCID 1363378112-(3-(5-Bromopyrazin-2-ylamino)-1H-pyrazol-5-yl)-3-methoxyphenol

생성물 1

HCID 86654391tert-Butyl 3-(2-(3-(5-bromopyrazin-2-ylamino)-1H-pyrazol-5-yl)-3-methoxyphenoxy)propylcarbamate수율 54%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

Diisopropyl azodicarboxylate (1.73 mL, 8.76 mmol) is added to a stirred solution of tert-butyl 3-hydroxypropylcarbamate (0.83 mL, 4.83 mmol), 2-(3-(5-bromopyrazin-2-ylamino)-1H-pyrazol-5-yl)-3-methoxyphenol) (1.59 g, 4.38 mmol) and polystyrene triphenylphosphine (5.91 g, 8.76 mmol) in THF (50 mL) at room temperature. After stirring for 45 min, the reaction is filtered, and the solvent is removed under reduced pressure. The resulting residue is chromatographed (methanol/CH2Cl2) to afford 1.27 g (54%) of a yellow solid.

후처리

  1. filtrationthe reaction is filtered
  2. customthe solvent is removed under reduced pressure
  3. customThe resulting residue is chromatographed (methanol/CH2Cl2)

출처 및 근거

ORD 기록
ord-5f05a11c5db145a0b3799dda02358add
출처 데이터셋
uspto-grants-2012_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08314108B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트