Phenyl isocyanate → HCID 57917619, 화합물

반응식

[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[C:12]1([N:18]=[C:19]=[O:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[C:12]1([NH:18][C:19](=[O:20])[NH:1][C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

반응물 2

HCID 7672Phenyl isocyanate

HCID 737487Methyl 6-aminonicotinate

생성물 1

HCID 57917619HCID 57917619, 화합물수율 104%

반응 조건

온도: 100 °C

실험 절차

To a solution of methyl 6-aminonicotinate (500 mg, 3.29 mmol) in N,N-diemthylformamide (5 mL) was added phenyl isocyanate (358 μL, 3.29 mmol). The mixture was heated to 100° C. for 2 hours and was then concentrated under vacuum to give the title compound (928 mg).

후처리

concentrationwas then concentrated under vacuum

출처 및 근거

ORD 기록: ord-94ad57d707064f3e8c411c87b033b174
출처 데이터셋: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08314091B2

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