Potassium Hydroxide → 5-[(Tert-butoxy)carbonyl]pyrazine-2-carboxylic acid

HRID 1878374노트

반응식

HRID 1878374 반응식
[C:1]([O:5][C:6]([C:8]1[N:9]=[CH:10][C:11]([C:14]([O:16]CC)=[O:15])=[N:12][CH:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+]>CO>[C:1]([O:5][C:6]([C:8]1[N:9]=[CH:10][C:11]([C:14]([OH:16])=[O:15])=[N:12][CH:13]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 66878222HCID 66878222, 화합물

생성물 1

HCID 668782615-[(Tert-butoxy)carbonyl]pyrazine-2-carboxylic acid수율 97.9%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mixture of ethyl 5(tert-butoxycarbonyl)pyrazine-2-carboxylate (0.742 g, 2.78 mmol) and methanol (20 mL) was added potassium hydroxide (0.23 g, 4.1 mmol) in wafer (2 mL) and the reaction was stirred at room temperature overnight. The solvent was removed under vacuum and the residue was dissolved in wafer (5 mL) and acidified to pH 2 with 1M hydrochloric acid. The solid precipitate was collected by filtration to afford the title compound (0.61 g). MS (ESI) m/z 240.2 [M+H]+

후처리

  1. customThe solvent was removed under vacuum
  2. dissolutionthe residue was dissolved in wafer (5 mL)
  3. filtrationThe solid precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-d026c8b85c554e698687b34701d92487
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314091B2

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