Sodium Iodide → HCID 57917660, 화합물

HRID 1878433노트

반응식

HRID 1878433 반응식
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[C:6]([NH:8][CH:9]1[CH2:12][C:11]([F:14])([F:13])[CH2:10]1)=[O:7].[N:18]1([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>C(#N)C>[F:13][C:11]1([F:14])[CH2:12][CH:9]([NH:8][C:6]([C:5]2[CH:4]=[C:3]([CH:17]=[CH:16][CH:15]=2)[CH2:2][N:21]2[CH2:20][CH2:19][N:18]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:23][CH2:22]2)=[O:7])[CH2:10]1

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 143452tert-Butyl piperazine-1-carboxylateHCID 668783523-(chloromethyl)-N-(3,3-difluorocyclobutyl)benzamide

생성물 1

HCID 57917660HCID 57917660, 화합물수율 98.7%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

3-(Chloromethyl)-N-(3,3-difluorocyclobutyl)benzamide (12.82 mmol, 3.33 g), tert-butyl piperazine-1-carboxylate (12.82 mmol, 2.388 g), potassium carbonate (38.5 mmol, 5.32 g) and sodium iodide (2.56 mmol, 0.384 g) were combined and heated at reflux in acetonitrile (50 ml) for 2 hours. The solvent was removed under reduced pressure and the residue taken up in dichloromethane, washed with water, dried over sodium sulfate and concentrated under vacuum to afford the title compound (5.179 g).

후처리

  1. temperatureheated
  2. customThe solvent was removed under reduced pressure
  3. washwashed with water
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-97e3627ab6f8437cb5236f74099bc6a5
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314091B2

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