Ethyl 6-Cyanoimidazo[1,2-a]pyridine-2-carboxylate → N-phenyl-6-cyanoimidazo[1,2-a]pyridine-2-carboxamide

반응식

Br[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[O:12])[N:10]=2)[CH:7]=1.[C:20](C1C=CC2N(C=C(C(OCC)=O)N=2)C=1)#[N:21]>>[C:14]1([NH:13][C:11]([C:9]2[N:10]=[C:5]3[CH:4]=[CH:3][C:2]([C:20]#[N:21])=[CH:7][N:6]3[CH:8]=2)=[O:12])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

반응물 2

HCID 10512851Ethyl 6-Cyanoimidazo[1,2-a]pyridine-2-carboxylate

HCID 247716736-bromo-N-phenylimidazo[1,2-a]pyridine-2-carboxamide

생성물 1

HCID 44135940N-phenyl-6-cyanoimidazo[1,2-a]pyridine-2-carboxamide

실험 절차

By working in the same manner as for the preparation of Intermediate 1, replacing the ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate with ethyl 6-cyanoimidazo[1,2-a]pyridine-2-carboxylate (J. Med. Chem. (1998), 41(22), 4317), N-phenyl-6-cyanoimidazo[1,2-a]pyridine-2-carboxamide is obtained in the form of a yellow solid

출처 및 근거

ORD 기록: ord-4de6b3e77fcd4eaaa30d0ffe40bfd9b6
출처 데이터셋: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08314109B2

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