Morpholine → 5-Chloro-7-(4-morpholinyl)-2-phenylpyrazolo[1,5-a]pyrimidine

HRID 1878517노트

반응식

HRID 1878517 반응식
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1.[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 49761343HCID 49761343, 화합물

생성물 1

HCID 585311415-Chloro-7-(4-morpholinyl)-2-phenylpyrazolo[1,5-a]pyrimidine수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

There was dissolved, in 1,4-dioxane (4 mL), 5,7-dichloro-2-phenyl-pyrazolo-[1,5-a]pyrimidine (168 mg, 0.637 mM), morpholine (111 μL, 1.27 mM) was added to the resulting solution and the mixture was stirred at room temperature for 15 minutes. The solvent was distilled off from the reaction mixture, the resulting residue was diluted with water and then extracted with methylene chloride. The extracts thus obtained were combined, dried over anhydrous sodium sulfate, the solvent was distilled off, and the resulting solid was washed with methanol to thus obtain the title compound (200 mg, yield: 100%).

후처리

  1. distillationThe solvent was distilled off from the reaction mixture
  2. additionthe resulting residue was diluted with water
  3. extractionextracted with methylene chloride
  4. customThe extracts thus obtained
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationthe solvent was distilled off
  7. washthe resulting solid was washed with methanol

출처 및 근거

ORD 기록
ord-0a3df806d038465d8e597aff7cf0abe2
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314098B2

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