Morpholine → 5-Chloro-7-morpholin-4-yl-3-phenyl-pyrazolo[1,5-a]pyrimidine

HRID 1878524노트

반응식

HRID 1878524 반응식
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[CH:10][C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:4]2[N:3]=1.[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[N:5]2[N:9]=[CH:10][C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[C:4]2[N:3]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 134659465,7-Dichloro-3-phenylpyrazolo[1,5-a]pyrimidine

생성물 1

HCID 585311525-Chloro-7-morpholin-4-yl-3-phenyl-pyrazolo[1,5-a]pyrimidine수율 82%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

There was dissolved, in 1,4-dioxane (2 mL), 5,7-dichloro-3-phenyl-pyrazolo-[1,5-a]pyrimidine (47.7 mg, 0.181 mM), then morpholine (31.6 μL, 0.362 mM) was added to the solution and the resulting mixture was stirred at room temperature for 30 minutes. The solvent was distilled off from this reaction mixture, the resulting residue was diluted with water and extracted with methylene chloride. The extracts thus obtained were combined, dried over anhydrous sodium sulfate, the solvent was then distilled off, and the resulting solid was washed with methanol to thus obtain the title compound (46.8 mg, yield: 82%).

후처리

  1. distillationThe solvent was distilled off from this reaction mixture
  2. additionthe resulting residue was diluted with water
  3. extractionextracted with methylene chloride
  4. customThe extracts thus obtained
  5. dry with materialdried over anhydrous sodium sulfate
  6. distillationthe solvent was then distilled off
  7. washthe resulting solid was washed with methanol

출처 및 근거

ORD 기록
ord-367618bb276044539d6052317857ad8c
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314098B2

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