Potassium Carbonate → HCID 86659718, 화합물

HRID 1878552노트

반응식

HRID 1878552 반응식
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1.Cl.[OH:19][CH:20]1[CH2:23][NH:22][CH2:21]1.C(=O)([O-])[O-].[K+].[K+]>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([N:22]2[CH2:23][CH:20]([OH:19])[CH2:21]2)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 27592903-Hydroxyazetidine hydrochlorideHCID 49761343HCID 49761343, 화합물

생성물 1

HCID 86659718HCID 86659718, 화합물수율 58%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

There was dissolved, in 1,4-dioxane (2 mL), 5,7-dichloro-2-phenyl-pyrazolo-[1,5-a]pyrimidine (64.5 mg, 0.244 mM), then 3-hydroxy-azetidine hydrochloride (29.4 mg, 0.268 mM) and potassium carbonate (74.2 mg, 0.537 mM) were added to the solution and the mixture was stirred at room temperature for 3 hours. The solvent was removed from this reaction mixture through distillation, the resulting residue was diluted with water and then extracted with methylene chloride. The resulting extracts were combined, dried over anhydrous sodium sulfate, the solvent was distilled off and the resulting solid was washed with diethyl ether to thus give the title compound (42.4 mg, yield: 58%).

후처리

  1. customThe solvent was removed from this reaction mixture through distillation
  2. additionthe resulting residue was diluted with water
  3. extractionextracted with methylene chloride
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationthe solvent was distilled off
  6. washthe resulting solid was washed with diethyl ether

출처 및 근거

ORD 기록
ord-3f5e69dc631d419f9bb7b896f209f585
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314098B2

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