Thiazolidine → HCID 86659720, 화합물

HRID 1878553노트

반응식

HRID 1878553 반응식
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1.[S:18]1[CH2:22][CH2:21][NH:20][CH2:19]1>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([N:20]2[CH2:21][CH2:22][S:18][CH2:19]2)[N:5]2[N:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:11]=[C:4]2[N:3]=1

참가 물질

4

반응물 2

HCID 10444ThiazolidineHCID 49761343HCID 49761343, 화합물

생성물 1

HCID 86659720HCID 86659720, 화합물수율 78%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

There was dissolved, in 1,4-dioxane (2 mL), 5,7-dichloro-2-phenyl-pyrazolo-[1,5-a]pyrimidine (51.4 mg, 0.195 mM), then thiazolidine (30.7 μL, 0.390 mM) was added to the solution and then the mixture was stirred at room temperature for one hour. The solvent was distilled off from this reaction mixture, the resulting residue was diluted with water and then extracted with ethyl acetate. The resulting extracts were combined, dried over anhydrous sodium sulfate, the solvent was distilled off and the resulting solid was washed with methanol to thus give the title compound (48.5 mg, yield: 78%).

후처리

  1. distillationThe solvent was distilled off from this reaction mixture
  2. additionthe resulting residue was diluted with water
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationthe solvent was distilled off
  6. washthe resulting solid was washed with methanol

출처 및 근거

ORD 기록
ord-6c73467d72b04dd38669dfa6275fc889
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314098B2

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