Trifluoroacetic acid → HCID 77967102, 화합물

HRID 1878557노트

반응식

HRID 1878557 반응식
FC(F)(F)C(O)=O.[N:8]1([C:14]2[N:19]3[N:20]=[C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:22]=[C:18]3[N:17]=[C:16]([NH:29][NH2:30])[CH:15]=2)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1.[C:31]([C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][CH:40]=1)[CH:36]=O)#[N:32]>C(O)C>[C:31]([C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][CH:40]=1)[CH:36]=[N:30][NH:29][C:16]1[CH:15]=[C:14]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[N:19]2[N:20]=[C:21]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:22]=[C:18]2[N:17]=1)#[N:32]

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 90670m-FormylbenzonitrileHCID 70867226HCID 70867226, 화합물

생성물 1

HCID 77967102HCID 77967102, 화합물수율 109.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

There was dissolved, in ethanol (2 mL), trifluoroacetic acid salt of (7-morpholin-4-yl-2-phenyl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (30.0 mg, 0.0557 mM), then 3-cyano-benzaldehyde (6.7 mg, 0.061 mM) was added to the solution and the mixture was stirred at room temperature for one hour. This reaction liquid was filtered and the resulting solid was purified by the NH-silica gel column chromatography (methanol/methylene chloride=1/20) to thus give the title compound (23.6 mg, yield: quantitative).

후처리

  1. customThis reaction liquid
  2. filtrationwas filtered
  3. customthe resulting solid was purified by the NH-silica gel column chromatography (methanol/methylene chloride=1/20)

출처 및 근거

ORD 기록
ord-9974cd28abf5462ead5a40e135afc199
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314098B2

반응 노트

불러오는 중…