3-Isopropylbenzaldehyde → HCID 77933899, 화합물

HRID 1878589노트

반응식

HRID 1878589 반응식
[N:1]1([C:7]2[N:12]3[N:13]=[C:14]([C:16]4[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=4)[CH:15]=[C:11]3[N:10]=[C:9]([NH:22][NH2:23])[CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=O)([CH3:26])[CH3:25]>C(O)C>[CH:24]([C:27]1[CH:28]=[C:29]([CH:32]=[CH:33][CH:34]=1)[CH:30]=[N:23][NH:22][C:9]1[CH:8]=[C:7]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)[N:12]2[N:13]=[C:14]([C:16]3[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=3)[CH:15]=[C:11]2[N:10]=1)([CH3:26])[CH3:25]

참가 물질

4

반응물 2

HCID 5206803-IsopropylbenzaldehydeHCID 70867116HCID 70867116, 화합물

생성물 1

HCID 77933899HCID 77933899, 화합물수율 26.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

There was dissolved, in ethanol (2 mL), (7-morpholin-4-yl-2-pyridin-4-yl-pyrazolo[1,5-a]pyrimidin-5-yl)-hydrazine (30.1 mg, 0.0967 mM), then 3-isopropyl-benzaldehyde (14.3 mg, 0.0967 mM) was added to the solution and the mixture was stirred at room temperature overnight. The solvent was distilled off from this reaction liquid, the resulting residue was purified by the reversed phase HPLC and then subjected to a desalting treatment to thus give the title compound (11.3 mg, yield: 26%).

후처리

  1. distillationThe solvent was distilled off from this reaction liquid
  2. customthe resulting residue was purified by the reversed phase HPLC

출처 및 근거

ORD 기록
ord-055a341b2fd14d15b0f9319f12ba2c77
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314098B2

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