Water → HCID 86632433, 화합물

HRID 1878627노트

반응식

HRID 1878627 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][CH2:10][OH:11])[CH:5]=[N:6][CH:7]=1.[CH3:12][S:13](Cl)(=[O:15])=[O:14].O>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([C:8]#[C:9][CH2:10][O:11][S:13]([CH3:12])(=[O:15])=[O:14])[CH:5]=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 242291823-(5-Bromopyridin-3-yl)prop-2-yn-1-ol2회

생성물 1

HCID 86632433HCID 86632433, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

3-(5-Bromo-pyridin-3-yl)-prop-2-yn-1-ol (Intermediate 218) (1 eq, 2.41 mmol, 510 mg) is dissolved in DCM (5 ml), then TEA (1.5 eq, 3.61 mmol, 0.5 ml) and methanesulfonyl chloride (1.5 eq, 3.61 mmol, 0.28 ml) are added. The resulting mixture is stirred for 30 min at r.t. After addition of water the layers are separated, and the organic layer is dried with MgSO4, filtered, and concentrated under reduced pressure giving the title compound.

후처리

  1. customare separated
  2. dry with materialthe organic layer is dried with MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a4fd545fd7784c1ba9cd5b6db5c04699
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314112B2

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