Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromo-5-fluoropyridine → 3-Fluoro-5-(pyridin-4-yl)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromo-5-fluoropyridine | HCID 820206 | — |
| 반응물 | (Pyridin-4-yl)boronic acid | HCID 2734379 | — |
| 생성물 | 3-Fluoro-5-(pyridin-4-yl)pyridine | HCID 46315823 | — |
반응 단계
Prepared from 3-bromo-5-fluoropyridine (439.0 mg, 2.50 mmol) and pyridin-4-ylboronic acid (509.9 mg, 3.73 mmol) according to Method K, except the product was purified by silica gel chromatography (ethyl acetate, Rf=0.21) instead of preparative HPLC; 1H NMR (300 MHz, chloroform-D) δ ppm 7.50-7.51 (m, 2H), 7.65 (dt, J=9.1, 2.4 Hz, 1H), 8.56 (d, J=2.8 Hz, 1H), 8.73-8.76 (m, 3H). MS (DCI/NH3) m/z=175 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08314119B2 |
| 출처 데이터셋 | uspto-grants-2012_11 |
| ORD ID | ord-c4625ac40488463aae1179e809f2e23c |
| 출처 메모 | uspto-grants-2012_11 |