Hydrazine → 2-(2-aminoethyl)-6-phenylpyridazin-3(2H)-one

HRID 1878742노트

반응식

HRID 1878742 반응식
[O:1]=[C:2]1[N:7]([CH2:8][CH2:9][N:10]2C(=O)C3C(=CC=CC=3)C2=O)[N:6]=[C:5]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:4]=[CH:3]1.NN>CO>[NH2:10][CH2:9][CH2:8][N:7]1[C:2](=[O:1])[CH:3]=[CH:4][C:5]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[N:6]1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 13103521HCID 13103521, 화합물

생성물 1

HCID 129026032-(2-aminoethyl)-6-phenylpyridazin-3(2H)-one

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
75 °C

실험 절차

A mixture of 2-(2-(6-oxo-3-phenylpyridazin-1(6H)-yl)ethyl)isoindoline-1,3-dione (2.1 g, 6.1 mmol) and hydrazine (10 mL, 10.0 mmol) (THF) in MeOH (40 mL) was heated to 75° C. A clear solution was formed. After overnight (18 h), the slurry was cooled to room temperature and was filtered and washed with MeOH. The filtrate was concentrated and washed with 20% MeOH/CH2Cl2 to give a yellow solid (LCMS indicated the presence of product). The filtrate was concentrated under vacuum and was carried to next step.

후처리

  1. customA clear solution was formed
  2. temperaturethe slurry was cooled to room temperature
  3. filtrationwas filtered
  4. washwashed with MeOH
  5. concentrationThe filtrate was concentrated
  6. washwashed with 20% MeOH/CH2Cl2
  7. customto give a yellow solid (LCMS
  8. concentrationThe filtrate was concentrated under vacuum

출처 및 근거

ORD 기록
ord-06085f8a8f524b67a71ae8284e771fcb
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314087B2

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