Triethylamine → HCID 59760051, 화합물

HRID 1879128노트

반응식

HRID 1879128 반응식
C(N(CC)CC)C.[Cl:8][C:9]1[CH:10]=[C:11]([CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([CH3:26])=[C:21]([CH:25]=2)[C:22](Cl)=[O:23])[CH:12]=[CH:13][CH:14]=1.[NH2:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36])=[CH:30][C:29]=1[CH3:40]>ClCCl.C(#N)C>[Cl:8][C:9]1[CH:10]=[C:11]([CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([CH3:26])=[C:21]([C:22]([NH:27][C:28]3[CH:33]=[CH:32][C:31]([CH2:34][C:35]([O:37][CH2:38][CH3:39])=[O:36])=[CH:30][C:29]=3[CH3:40])=[O:23])[CH:25]=2)[CH:12]=[CH:13][CH:14]=1

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 23511836HCID 23511836, 화합물HCID 59760053HCID 59760053, 화합물

생성물 1

HCID 59760051HCID 59760051, 화합물

시약·촉매·용매 2

HCID 6342Acetonitrile용매HCID 6344Dichloromethane용매

실험 절차

Triethylamine (74 ul, 0.53 mmol, 1.5 eq) was added to a suspension of 5-{[(3-chlorophenyl)methyl]oxy}-2-methylbenzoylchloride (105 mgs, 0.36 mmol) and ethyl (4-amino-3-methylphenyl)acetate (103 mg, 0.53 mmol, 1.5 eq) in dichloromethane (5 ml). The mixture was stirred at room temperature overnight. The mixture was then diluted with acetonitrile and purified by SCX cartridge (5 g) eluting with acetonitrile. Fractions containing product were combined and evaporated to give the title compound as a yellow gum, 174 mg. MS (ES+) m/z 452 [M+H]+ (C26H2635ClNO4).

후처리

  1. custompurified by SCX cartridge (5 g)
  2. washeluting with acetonitrile
  3. additionFractions containing product
  4. customevaporated

출처 및 근거

ORD 기록
ord-913468b7e6774d879fec58c4a3078719
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314147B2

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