Methanol → HCID 131727892, 화합물

HRID 1879430노트

반응식

HRID 1879430 반응식
[F:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:5]=[CH:4][C:3]=1[C:13]1[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=1.S(=O)(=O)(O)O.[CH3:28]O>>[F:1][C:2]1[C:3]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:20])([F:21])[F:22])=[CH:15][CH:14]=2)=[CH:4][CH:5]=[C:6]([CH:8]([CH3:12])[C:9]([O:11][CH3:28])=[O:10])[CH:7]=1

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 99727752-(2-Fluoro-4'-trifluoromethylbiphenyl-4-yl)propionic acid

생성물 1

HCID 131727892HCID 131727892, 화합물수율 95%

실험 절차

A solution of 2-(2-fluoro-4′-trifluoromethylbiphenyl-4-yl)propionic acid (0.2 g, 0.64 mmoles) in methanol (3 ml) is added with 98% sulfuric acid (0.5 g) and refluxed for 2.5 hours. The solvent is removed under vacuum, the residue is taken up with ethyl acetate (5 ml) and washed with a 5% NaHCO3 solution (5 ml), then with water. The solution is dried over Na2SO4 and concentrated under vacuum to afford an oil (0.2 g, 95%).

후처리

  1. temperaturerefluxed for 2.5 hours
  2. customThe solvent is removed under vacuum
  3. washwashed with a 5% NaHCO3 solution (5 ml)
  4. dry with materialThe solution is dried over Na2SO4
  5. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-b76ef07dc68448f0b0dcc3047e3e5fec
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314268B2

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