Methanol → N-Isopropyl 4-bromo-2-nitroaniline

HRID 1879450노트

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HRID 1879450 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5](F)=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1.[CH:12]([NH2:15])([CH3:14])[CH3:13].CO>ClCCl.O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:15][CH:12]([CH3:14])[CH3:13])=[C:4]([N+:9]([O-:11])=[O:10])[CH:3]=1

참가 물질

6

반응물 3

HCID 887MethanolHCID 6363IsopropylamineHCID 27363284-Bromo-1-fluoro-2-nitrobenzene

생성물 1

HCID 2759489N-Isopropyl 4-bromo-2-nitroaniline

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

To a stirred, cold (0° C.) solution of 4-bromo-1-fluoro-2-nitrobenzene (7 g, 32 mmol) in dichloromethane (100 mL) was added isopropylamine (5 mL, 64 mmol). The mixture was allowed to stir at 0° C. for 3 h and room temperature overnight. It was diluted with water and extracted with CH2Cl2. The organic layer was washed with water and brine, dried (MgSO4), and filtered. The filtrate was concentrated in vacuo to give a crude red solid. Trituration with MeOH afforded the title compound as an orange-red solid. MS (ESI, pos. ion) m/z: 260.7 (M+1).

후처리

  1. extractionextracted with CH2Cl2
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated in vacuo
  6. customto give a crude red solid

출처 및 근거

ORD 기록
ord-99b9fbcff799424897ed548cf25fca3c
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314131B2

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