참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-Bromopropionic acid | HCID 11553 | — |
| 반응물 | 2,3,3-Trimethylbenzoindolenine | HCID 170530 | — |
| 용매 | 1,2-Dichlorobenzene | HCID 7239 | — |
| 생성물 | 1,1,2-trimethyl[1H]-benz[e]indole-3-propanoic acid | HCID 66986925 | 112.2% |
반응 단계
A mixture of 1,1,2-trimethyl[1H]-benz[e]indole (10.0 g, 47.8 mmol) and 3-bromopropanoic acid (7.3 g, 47.8 mmol) in 1,2-dichlorobenzene (50 mL) was heated with stirring at 110° C. for 18 h. After the resulting mixture was cooled to room temperature, the precipitated was collected by filtration, triturated with DCM thoroughly, and dried under vacuum to afford 15.2 g of light brown powder (88%). ESI-MS: observed for [MH]+281.31.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08318133B2 |
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| 출처 데이터셋 | uspto-grants-2012_11 |
|---|
| ORD ID | ord-6b98eb3eef874f4598a57fcbdcc3693e |
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| 출처 메모 | uspto-grants-2012_11 |
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