N-methyl-2-pyrrolidone → 3-Chloro-2-isopropylsulfonyl-1-nitrobenzene
반응식
[CH:1]([S:4]([O-:6])=[O:5])([CH3:3])[CH3:2].[Na+].CN1CCCC1=O.Cl[C:16]1[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=1[N+:23]([O-:25])=[O:24]>O>[Cl:22][C:21]1[C:16]([S:4]([CH:1]([CH3:3])[CH3:2])(=[O:6])=[O:5])=[C:17]([N+:23]([O-:25])=[O:24])[CH:18]=[CH:19][CH:20]=1참가 물질
5
반응 조건
- 온도
- 70 °C
실험 절차
To a mixture of sodium isopropylsulfinate (3.3 g) and N-methyl-2-pyrrolidinone (20 mL), 2,3-dichloronitrobenzene (4 g) was added and stirred overnight at 70° C. The reaction mixture was diluted with water, and the precipitated solid was collected by filtration and washed with diethyl ether to give 3-chloro-2-isopropylsulfonyl-1-nitrobenzene (3.0 g) as a white solid.
후처리
- additionwas added
- filtrationthe precipitated solid was collected by filtration
- washwashed with diethyl ether
출처 및 근거
- ORD 기록
- ord-13d5fda60e4d4100b3cdfdeaab8f0bcc
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08318702B2
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