Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Alcohol → Ethyl 2-(benzyloxy)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Alcohol | HCID 244 | — |
| 반응물 | Ethyl diazoacetate | HCID 12192 | — |
| 촉매 | Acetic acid, rhodium salt (4:2) | HCID 423677 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl 2-(benzyloxy)acetate | HCID 290299 | 93.2% |
반응 단계
To a solution of benzyl alcohol (1.04 mL, 10.0 mmol) in dichloromethane (30 mL) is added rhodium (II) acetate dimer (40 mg) followed by ethyl diazoacetate (1.14 g, 10.0 mmol). The reaction mixture is stirred at RT for 20 min. The reaction mixture is rotary evaporated, and the residue is vacuum distilled at 110° C. to give 1.81 g of the product 390. 1H NMR (CDCl3) δ 7.4-7.26 (m, 5H), 4.65 (s, 2H), 4.23 (q, 2H), 4.10 (s, 2H), 1.30 (t, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741493B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-8049abc59b7d4bb6ae237a480e07cebf |
| 출처 메모 | uspto-grants-2010_06 |