Acetic Acid → 2-Oxopropanal isopropylhydrazone

HRID 1880329노트

반응식

HRID 1880329 반응식
Cl.[CH:2]([NH:5][NH2:6])([CH3:4])[CH3:3].C(O)(=O)C.[CH:11](=O)[C:12]([CH3:14])=[O:13]>O>[CH:2]([NH:5][N:6]=[CH:11][C:12](=[O:13])[CH3:14])([CH3:4])[CH3:3]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 880MethylglyoxalHCID 855731-Isopropylhydrazine hydrochloride

생성물 1

HCID 866504872-Oxopropanal isopropylhydrazone수율 69.9%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a solution of isopropylhydrazine hydrochloride (2.0 g, 18 mmol) in water (100 mL) was added acetic acid (1.7 mL) followed by the dropwise addition of pyruvaldehyde (2.6 g, 14.5 mmol) in water. The solution was stirred at room temperature overnight. The aqueous layer was extracted with CH2Cl2 (4×) and the combined organic extracts were washed with sat. aq. NaHCO3. The organic extract was dried over Na2SO4, filtered and concentrated to afford 2-oxopropanal isopropylhydrazone (1.3 g, 56%).

후처리

  1. extractionThe aqueous layer was extracted with CH2Cl2 (4×)
  2. washthe combined organic extracts were washed with sat. aq. NaHCO3
  3. extractionThe organic extract
  4. dry with materialwas dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-353c7a00660c45548282080a312558dd
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318762B2

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