Chlorosuccinimide → 1-(2-Amino-5-bromo-3-chlorophenyl)ethanone
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10].[Cl:12]N1C(=O)CCC1=O>C(Cl)Cl>[NH2:1][C:2]1[C:7]([Cl:12])=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[C:9](=[O:11])[CH3:10]참가 물질
4
실험 절차
To a solution of 1-(2-amino-5-bromophenyl)ethanone (200 mg, 0.93 mmol) in CH2Cl2 (5 mL) was added N-chlorosuccinimide (125 mg, 0.93 mmol). The mixture was stirred at room temperature overnight. Analysis indicated that the reaction was incomplete; therefore, additional N-chlorosuccinimide (125 mg, 0.93 mmol) was added and the mixture was stirred at room temperature overnight. The solvents were removed under reduced pressure and the residue was purified by CombiFlash (40 g column, 0-10% EtOAc/heptane) to afford 1-(2-amino-5-bromo-3-chlorophenyl)ethanone (206 mg, 89%).
후처리
- stirringthe mixture was stirred at room temperature overnight
- customThe solvents were removed under reduced pressure
- customthe residue was purified by CombiFlash (40 g column, 0-10% EtOAc/heptane)
출처 및 근거
- ORD 기록
- ord-2a9c91df13614deea504ccdadffb74a3
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08318762B2
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