Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl diazoacetate → (3-Trifluoromethylbenzyloxy)acetic Acid Ethyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl diazoacetate | HCID 12192 | — |
| 반응물 | 3-(Trifluoromethyl)benzylic alcohol | HCID 67681 | — |
| 촉매 | Acetic acid, rhodium salt (4:2) | HCID 423677 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Heptane | HCID 8900 | — |
| 생성물 | (3-Trifluoromethylbenzyloxy)acetic Acid Ethyl Ester | HCID 68572230 | 97.9% |
반응 단계
To a solution of 3-trifluoromethylbenzyl alcohol (1.62 g, 10.0 mmol) in dichloromethane (20 mL) is added rhodium (II) acetate dimer (10 mg) followed by ethyl diazoacetate (0.95 mL, 9.0 mmol). The reaction mixture is stirred at RT for 30 min. The reaction mixture is diluted with heptane, filtered through Celite, and the filtrate is evaporated and the residue is vacuum distilled at 150° C. to give 2.31 g of the product 394. 1H NMR (CDCl3) δ 7.65 (bs, 1H), 7.57 (m, 2H), 7.48 (t, 1H), 4.69 (s, 2H), 4.24 (q, 2H), 4.14 (s, 2H), 1.30 (t, 3H); MS: m/z 263 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741493B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-4849db3f64cf446ca8fa05063e74d175 |
| 출처 메모 | uspto-grants-2010_06 |