[3-Methyl-1-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-butyl]-carbamic acid benzyl ester → 3-Methyl-1-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-butylamine

HRID 1880555노트

반응식

HRID 1880555 반응식
C(OC(=O)[NH:10][CH:11]([C:16]12[O:23][CH2:22][C:19]([CH3:24])([CH2:20][O:21]1)[CH2:18][O:17]2)[CH2:12][CH:13]([CH3:15])[CH3:14])C1C=CC=CC=1>CCO.[Pd]>[CH3:14][CH:13]([CH3:15])[CH2:12][CH:11]([NH2:10])[C:16]12[O:17][CH2:18][C:19]([CH3:24])([CH2:20][O:21]1)[CH2:22][O:23]2

참가 물질

4

반응물 1

HCID 67298262[3-Methyl-1-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-butyl]-carbamic acid benzyl ester

생성물 1

HCID 574469573-Methyl-1-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-butylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To [3-methyl-1-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-butyl]-carbamic acid benzyl ester (3.2 g, 9.2 mmol) in absolute EtOH (30 mL) was added 10% Pd in activated carbon (320 mg, 10%) under nitrogen. The reaction mixture was hydrogenated at 50 psi for 6 h. The reaction was monitored by TLC and the reaction mixture was filtered through Celite. The solvent was removed to get 3-methyl-1-(4-methyl-2,6,7-trioxa-bicyclo[2.2.2]oct-1-yl)-butylamine as a white solid.

후처리

  1. filtrationthe reaction mixture was filtered through Celite
  2. customThe solvent was removed

출처 및 근거

ORD 기록
ord-e4449b10cc4340cda03e5743cb5d1b3c
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318748B2

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