Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,2-Dimethylbutyryl chloride → 4-(2,2-Dimethylbutanoyl)-3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,2-Dimethylbutyryl chloride | HCID 79958 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | HCID 178517507 | HCID 178517507 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 4-(2,2-Dimethylbutanoyl)-3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-one | HCID 59570388 | 56.2% |
반응 단계
To 1 ml of pyridine were added 0.3 g of 1,8-diazabicyclo[5,4,0]undec-7-ene, and 0.3 g of 3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-one, and 0.26 g of 2,2-dimethylbutanoyl chloride was added at room temperature. After stirring for 3 hours, the resultant solution was concentrated, and the residue was subjected to silica gel column chromatography to obtain 0.24 g of 4-(2,2-dimethylbutanoyl)-3-(4-trifluoromethylpyridin-2-yl)-1,2,4-oxadiazol-5-one (present compound (11)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08318776B2 |
| 출처 데이터셋 | uspto-grants-2012_11 |
| ORD ID | ord-6cb5c8e620264fd4933e8c95e2a4c590 |
| 출처 메모 | uspto-grants-2012_11 |