참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4-Iodopyridine | HCID 609492 | — |
| 반응물 | (3,3,3-Trifluoroprop-1-en-2-yl)boronic acid | HCID 2782677 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-[1-(Trifluoromethyl)ethenyl]pyridine | HCID 59570355 | 73.5% |
반응 단계
To 1,4-dioxane were added 3.22 g of 4-iodopyridine, 10.87 g of potassium carbonate, 0.036 g of tetrakis(triphenylphosphinepalladium) and 5.5 g of 1-(trifluoromethyl)vinylboronic acid, and the mixture was stirred at 110° C. for 8 hours. Thereafter, this solution was poured into an aqueous saturated ammonium chloride solution, followed by extraction with diethyl ether three times. The organic layers were combined, washed with an aqueous saturated sodium chloride solution, dried with anhydrous magnesium sulfate, and concentrated. The residue was subjected to silica gel column chromatography to obtain 2.0 g of 4-[1-(trifluoromethyl)ethenyl]pyridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08318776B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_11 |
|---|
| ORD ID | ord-9f0c2151f2b44a58a621a8a51def4c6e |
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| 출처 메모 | uspto-grants-2012_11 |
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