Trifluoroacetic acid → 2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine hydrochloride

HRID 1880780노트

반응식

HRID 1880780 반응식
[Cl:1][C:2]1[C:3]([CH:12]([CH2:22][CH3:23])[CH2:13][NH:14]C(=O)OC(C)(C)C)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.FC(F)(F)C(O)=O>ClCCl>[ClH:1].[Cl:1][C:2]1[C:3]([CH:12]([CH2:22][CH3:23])[CH2:13][NH2:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 23078240Tert-butyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butylcarbamate

생성물 1

HCID 667981942-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

146 g of tert-butyl 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]butylcarbamate (0.414 mol) are dissolved in 2 L of dichloromethane. 190 mL of trifluoroacetic acid are added dropwise. The reaction mixture is stirred at room temperature for twelve hours, concentrated to dryness and diluted in 300 mL of hydrochloric acid 2M.

후처리

  1. concentrationconcentrated to dryness
  2. additiondiluted in 300 mL of hydrochloric acid 2M

출처 및 근거

ORD 기록
ord-3321531559074af4b1ba5ee3022a6065
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318777B2

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