Acetyl chloride → N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl](cyano)methyl]acetamide
반응식
Cl.[NH2:2][CH:3]([C:6]1[C:11]([Cl:12])=[CH:10][C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][N:7]=1)[C:4]#[N:5].C(N(CC)CC)C.[C:24](Cl)(=[O:26])[CH3:25]>ClCCl>[Cl:12][C:11]1[C:6]([CH:3]([C:4]#[N:5])[NH:2][C:24](=[O:26])[CH3:25])=[N:7][CH:8]=[C:9]([C:13]([F:15])([F:16])[F:14])[CH:10]=1참가 물질
5
실험 절차
0.67 g of amino[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile hydrochloride (0.00245 mol) are dissolved in 15 mL of dichloromethane, 0.68 mL of triethylamine are added. After 10 min. at room temperature, 0.18 mL of acetyl chloride (0.00245 mol) are added, the reaction mixture is stirred overnight. The reaction is quenched with 20 mL of water.
후처리
- customThe reaction is quenched with 20 mL of water
출처 및 근거
- ORD 기록
- ord-b6bcd0b80cc6470f85a25c3e1b2b416c
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08318777B2
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