Diethyl Ether → Ethyl 2-(Benzylsulfanyl)acetate

HRID 18808

반응식

HRID 18808 반응식
[CH2:1]([SH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].CCOCC>CN(C=O)C>[CH2:20]([O:19][C:17](=[O:18])[CH2:16][S:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:21]

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 7509Benzyl mercaptanHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

생성물 1

HCID 3344750Ethyl 2-(Benzylsulfanyl)acetate수율 49.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of benzyl mercaptan (1.18 mL, 10.0 mmol) in DMF (20 mL) is added potassium carbonate (1.51 g, 10.9 mmol) and ethyl bromoacetate (1.17 mL, 10.6 mmol), and the mixture is stirred at RT for 25 min. Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled (130-140° C.) to give 1.05 g of the product 402.

후처리

  1. washthe mixture is washed with water, brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customThe filtrate is evaporated
  5. distillationdistilled (130-140° C.)

출처 및 근거

ORD 기록
ord-b23c6536424c4e7d8c34c22f26f46f35
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741493B2

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