Diethyl Ether → Ethyl 2-(Benzylsulfanyl)acetate
반응식
[CH2:1]([SH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].CCOCC>CN(C=O)C>[CH2:20]([O:19][C:17](=[O:18])[CH2:16][S:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:21]참가 물질
6
실험 절차
To a solution of benzyl mercaptan (1.18 mL, 10.0 mmol) in DMF (20 mL) is added potassium carbonate (1.51 g, 10.9 mmol) and ethyl bromoacetate (1.17 mL, 10.6 mmol), and the mixture is stirred at RT for 25 min. Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled (130-140° C.) to give 1.05 g of the product 402.
후처리
- washthe mixture is washed with water, brine
- dry with materialdried (MgSO4)
- filtrationfiltered
- customThe filtrate is evaporated
- distillationdistilled (130-140° C.)
출처 및 근거
- ORD 기록
- ord-b23c6536424c4e7d8c34c22f26f46f35
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07741493B2
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