Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → Ethyl isopropoxyacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Ethyl diazoacetate | HCID 12192 | — |
| 촉매 | Acetic acid, rhodium salt (4:2) | HCID 423677 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Ethyl isopropoxyacetate | HCID 537908 | 51.3% |
반응 단계
To a solution of 2-propanol (0.776 mL, 10.0 mmol) in dichloromethane (33 mL) is added rhodium (II) acetate dimer (22 mg) followed by ethyl diazoacetate (1.05 mL, 10.0 mmol). The reaction mixture is stirred at RT for 30 min. The reaction mixture is filtered through Celite, and the filtrate is evaporated and the residue is vacuum distilled at 150° C. to give 750 mg of the product 405. 1H NMR (CDCl3) δ 4.21 (q, 2 H), 4.06 (s, 2 H), 3.73 (m, 1 H), 1.29 (t, 3 H), 1.22 (s, 3 H), 1.19 (s, 3 H); MS: m/z 147 (M++1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741493B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-7777b2e233d64c81ae3edec4c6319a78 |
| 출처 메모 | uspto-grants-2010_06 |