Methanol → 4-(4-Hydroxyphenyl)butanoic acid methyl ester

HRID 1881030

반응식

HRID 1881030 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.O.[CH3:20]O>>[CH3:20][O:12][C:11](=[O:13])[CH2:10][CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1

참가 물질

5

반응물 4

HCID 887MethanolHCID 962WaterHCID 1118Sulfuric AcidHCID 2799834-(4-Hydroxyphenyl)butanoic acid

생성물 1

HCID 1409044-(4-Hydroxyphenyl)butanoic acid methyl ester수율 99%

실험 절차

The 4-(4-hydroxyphenyl)butanoic acid (1) (4.6 g) from the previous step was dissolved in methanol (60 mL), concentrated sulfuric acid (1 mL) was added, and refluxed by heating for two days. The reaction solution was poured into water, and extracted with ethyl acetate (200 mL). The organic layer was washed with water (50 mL), saturated aqueous solution of sodium hydrogen carbonate (50 mL) and saturated sodium chloride solution (50 mL). After drying on anhydrous sodium sulfate, filtration and vacuum concentration, the above-identified compound (4.9 g, yield 99%) was obtained.

후처리

  1. temperaturerefluxed
  2. temperatureby heating for two days
  3. extractionextracted with ethyl acetate (200 mL)
  4. washThe organic layer was washed with water (50 mL), saturated aqueous solution of sodium hydrogen carbonate (50 mL) and saturated sodium chloride solution (50 mL)
  5. dry with materialAfter drying on anhydrous sodium sulfate, filtration and vacuum concentration

출처 및 근거

ORD 기록
ord-ddabfb4001e74cad8d406a525cc3f8be
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318781B2

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