5-(4-Methoxyphenyl)-5-oxopentanoic acid → 5-(4-Methoxyphenyl)pentanoic acid

HRID 1881037노트

반응식

HRID 1881037 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:5][CH:4]=1>C(O)C.C(O)(=O)C.[H][H].[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])=[CH:7][CH:8]=1

참가 물질

6

반응물 1

HCID 2668175-(4-Methoxyphenyl)-5-oxopentanoic acid

생성물 1

HCID 3445015-(4-Methoxyphenyl)pentanoic acid수율 99.3%

시약·촉매·용매 4

HCID 23938Palladium촉매HCID 176Acetic Acid용매HCID 702Ethanol용매HCID 178418361HCID 178418361, 화합물용매

실험 절차

5-(4-methoxyphenyl)-5-oxopentanoic acid (8) (11.5 g) from the previous step was dissolved in ethyl alcohol (150 mL) and acetic acid (50 mL), 10% palladium-activated carbon (1.2 g) was added, then stirred overnight in hydrogen atmosphere at room temperature. After filtration and vacuum concentration, the above-identified compound was obtained as a colorless solid (10.7 g, yield 99%).

후처리

  1. filtrationAfter filtration and vacuum concentration

출처 및 근거

ORD 기록
ord-83bf6ed1cc98472680800b254f355b74
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318781B2

반응 노트

불러오는 중…