Nitric Acid → 3-Chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylic acid

HRID 1881161노트

반응식

HRID 1881161 반응식
[Cl:1][C:2]1[C:3]2[CH:13]=[C:12]([OH:14])[C:11]([OH:15])=[CH:10][C:4]=2[S:5][C:6]=1[C:7]([OH:9])=[O:8].[N+:16]([O-])([OH:18])=[O:17]>C(OCC)(=O)C.ClCCl>[Cl:1][C:2]1[C:3]2[CH:13]=[C:12]([OH:14])[C:11]([OH:15])=[C:10]([N+:16]([O-:18])=[O:17])[C:4]=2[S:5][C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

5

반응물 2

HCID 944Nitric AcidHCID 13575863478400-03-2

생성물 1

HCID 159829713-Chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylic acid

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

3-Chloro-5,6-dihydroxy-benzo[b]thiophene-2-carboxylic acid was dissolved in ethyl acetate and a solution of nitric acid in dichloromethane (2M, 0.38 ml) was gradually added at 20° C. The solution was stirred 10 min at room temperature and then it was poured into ice-cold water and extracted with ethyl acetate. The organic extracts were combined, dried and evaporated to dryness. The residue was recrystallized from acetic acid.

후처리

  1. additionit was poured into ice-cold water
  2. extractionextracted with ethyl acetate
  3. customdried
  4. customevaporated to dryness
  5. customThe residue was recrystallized from acetic acid

출처 및 근거

ORD 기록
ord-39ee5300668549faa3c61461776962b2
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318785B2

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