Nitric Acid → 2-Methyl-7-nitro-1,3-benzothiazole-5,6-diol

HRID 1881176노트

반응식

HRID 1881176 반응식
[CH3:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([OH:11])[C:8]([OH:12])=[CH:7][C:5]=2[N:6]=1.[N+:13]([O-])([OH:15])=[O:14]>C(OCC)(=O)C.ClCCl>[CH3:1][C:2]1[S:3][C:4]2[C:10]([N+:13]([O-:15])=[O:14])=[C:9]([OH:11])[C:8]([OH:12])=[CH:7][C:5]=2[N:6]=1

참가 물질

5

반응물 2

HCID 944Nitric AcidHCID 7369402-methyl-1,3-benzothiazole-5,6-diol

생성물 1

HCID 159831022-Methyl-7-nitro-1,3-benzothiazole-5,6-diol

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

2-Methyl-benzothiazole-5,6-diol was dissolved in ethyl acetate and a solution of nitric acid in dichloromethane (2M, 0.38 ml) was gradually added at 20° C. into. The solution was stirred 10 min at room temperature and then it was poured into ice water and extracted into ethyl acetate and evaporated. The product was purified by column chromatography using toluene-ethyl acetate-acetic acid 8:1:1 as the eluent.

후처리

  1. extractionextracted into ethyl acetate
  2. customevaporated
  3. customThe product was purified by column chromatography

출처 및 근거

ORD 기록
ord-93c972d9802948868638b6370fcf9ec8
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318785B2

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