Potassium Carbonate → 2-Chloro-5-(((3aS,6aS)-5-(ethoxycarbonyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)methyl)pyridine 1-oxide

HRID 1881337노트

반응식

HRID 1881337 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]Cl)=[CH:4][N+:3]=1[O-:10].[NH:11]1[CH2:15][CH2:14][C@H:13]2[CH2:16][N:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:18][C@@H:12]12.C([O-])([O-])=O.[K+].[K+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:11]2[CH2:15][CH2:14][C@H:13]3[CH2:16][N:17]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:18][C@@H:12]23)=[CH:4][N+:3]=1[O-:10]

참가 물질

4

반응물 3

HCID 11430Potassium CarbonateHCID 124874662-Chloro-5-chloromethylpyridine 1-oxideHCID 43604250(3AS,6AS)-5-Ethoxycarbonyl-1H-hexahydropyrrolo[3,4-B]pyrrole

생성물 1

HCID 866495632-Chloro-5-(((3aS,6aS)-5-(ethoxycarbonyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)methyl)pyridine 1-oxide

실험 절차

The titled compound was prepared in analogy to examples 2.2 and 2.3 using 2-chloro-5-(chloromethyl)pyridine 1-oxide (712 mg, 4 mmol), (3aS,6aS)-ethyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (1.1 g, 5.97 mmol), and K2CO3 (553 mg, 4 mmol). The obtained crude product was used without further purification in the next reaction step.

후처리

  1. customThe obtained crude product
  2. customwas used without further purification in the next reaction step

출처 및 근거

ORD 기록
ord-f6a1690384fd4803bf3d8e4e07014a2f
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318793B2

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