1,1'-Thiocarbonyldiimidazole → 5-Isothiocyanato-indan-2-ol

HRID 1881355노트

반응식

HRID 1881355 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([OH:11])[CH2:5]2.C1N=CN([C:17](N2C=NC=C2)=[S:18])C=1>C(Cl)Cl>[N:1]([C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH2:7][CH:6]([OH:11])[CH2:5]2)=[C:17]=[S:18]

참가 물질

4

반응물 2

HCID 802641,1'-ThiocarbonyldiimidazoleHCID 215550315-amino-2,3-dihydro-1H-inden-2-ol

생성물 1

HCID 866197015-Isothiocyanato-indan-2-ol수율 69%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

5-Amino-indan-2-ol (149 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and TCDI (thiocarbodiimidazole, 178 mg, 1 mmol) was added to the solution. The reaction mixture was stirred at room temperature for 30 min. Silica gel was added to the reaction mixture and dried. Purification of silica gel coated crude product by column chromatography (EtOAc:Hexane=3:7) afforded the title product as a white solid (132 mg).

후처리

  1. additionSilica gel was added to the reaction mixture
  2. customdried
  3. customPurification of silica gel coated crude product by column chromatography (EtOAc:Hexane=3:7)

출처 및 근거

ORD 기록
ord-8573e09a03784c55aa6bd940d12e446a
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318790B2

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