HCID 178442423, 화합물 → HCID 178442424, 화합물

HRID 1881493노트

반응식

HRID 1881493 반응식
[CH3:1][C:2]([CH3:37])([CH2:35][CH3:36])[CH2:3][C:4]1[N:5]=[C:6]([C:9]2([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][N:29]=4)=[CH:24][CH:23]=3)[CH2:13][CH2:12][CH2:11][N:10]2C(OC(C)(C)C)=O)[NH:7][CH:8]=1>FC(F)(F)C(O)=O>[CH3:1][C:2]([CH3:37])([CH2:35][CH3:36])[CH2:3][C:4]1[N:5]=[C:6]([C:9]2([CH2:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][N:29]=4)=[CH:24][CH:23]=3)[CH2:13][CH2:12][CH2:11][NH:10]2)[NH:7][CH:8]=1

참가 물질

3

반응물 1

HCID 178442423HCID 178442423, 화합물

생성물 1

HCID 178442424HCID 178442424, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

tert-Butyl 2-[4-(2,2-dimethylbutyl)-1H-imidazol-2-yl]-2-[4-(5-fluoropyridin-2-yl)benzyl]pyrrolidine-1-carboxylate (45 mg, 0.089 mmol) was dissolved in trifluoroacetic acid (1 mL). After stirring at ambient temperature overnight, the reaction mixture was concentrated in vacuo to afford the title compound. 1H NMR (500 MHz, CD3OD) δ 8.48 (d, J=2.5 Hz, 1H), 8.28 (br s, 1H), 7.83 (dd, J=8.7, 4.2 Hz, 1H), 7.79 (d, J=8.0 Hz, 2H), 7.64 (td, J=8.5, 3.0 Hz, 1H), 6.97 (d, J=8.0 Hz, 2H), 6.86 (s, 1H), 3.45-3.39 (m, 3H), 3.24-3.17 (m, 1H), 2.52-2.41 (m, 1H), 2.45 (s, 2H), 2.33-2.25 (m, 1H), 2.22-2.13 (m, 1H), 1.91-1.82 (m, 1H), 1.22 (q, J=15.0, 7.5 Hz, 2H), 0.84 (t, J=7.5 Hz, 3H), 0.81 (s, 6H). (M+H) found: 407.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-54f91ad7beb24140bae8eec3356ea7f0
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318767B2

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