Methyl 4-benzyloxycarbonyl-2-fluorobenzoate → 1-Methyl 2-fluoro-1,4-benzenedicarboxylate
반응식
C([O:8][C:9]([C:11]1[CH:20]=[CH:19][C:14]([C:15]([O:17][CH3:18])=[O:16])=[C:13]([F:21])[CH:12]=1)=[O:10])C1C=CC=CC=1>C(O)C.[C].[Pd]>[F:21][C:13]1[CH:12]=[C:11]([CH:20]=[CH:19][C:14]=1[C:15]([O:17][CH3:18])=[O:16])[C:9]([OH:10])=[O:8]참가 물질
4
실험 절차
Catalytic amount of 10 wt % palladium carbon was added to a solution of methyl 4-benzyloxycarbonyl-2-fluorobenzoate (35.4 mg, 0.123 mmol) in ethanol (2 mL), and the mixture was stirred overnight at room temperature under hydrogen atmosphere. After completion of the reaction, the mixture was filtered through celite and the filtrate was concentrated to obtain 26.0 mg of the desired product as a colorless solid (yield 100%).
후처리
- customAfter completion of the reaction
- filtrationthe mixture was filtered through celite
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-0f5ca2c817e24164acace9600302d093
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08318796B2
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