참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | 4-Methoxycarbonyl-3-nitrophenyl isothiocyanate | HCID 86014591 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl 4-hydrazinocarbonothioylamino-2-nitrobenzoate | HCID 86014590 | 85% |
반응 단계
A solution of the above synthesized 4-methoxycarbonyl-3-nitrophenyl isothiocyanate (149 mg, 0.62 mmol) in tetrahydrofuran (2.2 ml) was added dropwise to a solution of hydrazine monohydrate (94 mg, 1.87 mmol) in tetrahydrofuran (4.0 ml) at 0° C. over 20 minutes. After stirring at 0° C. for further 40 minutes, water was added, and the precipitated solid was filtered to obtain 142 mg of the desired product as a colorless solid (yield 85%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08318796B2 |
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| 출처 데이터셋 | uspto-grants-2012_11 |
|---|
| ORD ID | ord-bd51343a360a44a7bdf07dfa33514e1f |
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| 출처 메모 | uspto-grants-2012_11 |
|---|
