HCID 25234930, 화합물 → Apricitabine
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C([O:9][CH2:10][C@H:11]1[S:15][C@@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH:21]C(=O)C3C=CC=CC=3)=[N:19][C:17]2=[O:18])[CH2:13][O:12]1)(=O)C1C=CC=CC=1>N>[OH:9][CH2:10][C@H:11]1[S:15][C@@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH2:21])=[N:19][C:17]2=[O:18])[CH2:13][O:12]1참가 물질
3
시약·촉매·용매 1
실험 절차
2-(R)-benzoyloxymethyl-4-(R)—(N-benzoylcytosin-1-yl)-1,3-oxathiolane (15 g, 0.028 mol) was dissolved in a methanolic ammonia (approximately 2M) solution (250 mL). The initial slurry was stirred overnight. After overnight stirring, the resulting clear solution was filtered through celite, evaporated to dryness and slurried in acetone (100 mL). This yielded off-white powdery solid which was filtered and washed with acetone (2×25 mL), and dried to yield the product. 6.5 g (94%).
후처리
- stirringAfter overnight stirring
- filtrationthe resulting clear solution was filtered through celite
- customevaporated to dryness
- filtrationThis yielded off-white powdery solid which was filtered
- washwashed with acetone (2×25 mL)
- customdried
- customto yield the product
출처 및 근거
- ORD 기록
- ord-8dc363a5b27a4881b04796ad5fefc4e5
- 출처 데이터셋
- uspto-grants-2012_11
- 특허 번호
- US08318934B2
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