HCID 25234931, 화합물 → Apricitabine, (+)-

HRID 1881706노트

반응식

HRID 1881706 반응식
C([O:9][CH2:10][C@@H:11]1[S:15][C@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH:21]C(=O)C3C=CC=CC=3)=[N:19][C:17]2=[O:18])[CH2:13][O:12]1)(=O)C1C=CC=CC=1>N>[OH:9][CH2:10][C@@H:11]1[S:15][C@H:14]([N:16]2[CH:31]=[CH:30][C:20]([NH2:21])=[N:19][C:17]2=[O:18])[CH2:13][O:12]1

참가 물질

3

반응물 1

HCID 25234931HCID 25234931, 화합물

생성물 1

HCID 468214Apricitabine, (+)-

시약·촉매·용매 1

HCID 222Ammonia용매

실험 절차

2-(S)-benzoyloxymethyl-4-(S)—(N-benzoylcytosin-1-yl)-1,3-oxathiolane (1.0 g, 0.0022 mol) was dissolved in a methanolic ammonia (approximately 2M) solution (20 mL). The initial slurry was stirred overnight. After overnight stirring, the resulting clear solution was evaporated to dryness and slurried in acetone (20 mL). This yielded off-white powdery solid which was filtered and washed with acetone (2×10 mL), and dried to yield the product. 0.47 g (88%).

후처리

  1. stirringAfter overnight stirring
  2. customthe resulting clear solution was evaporated to dryness
  3. filtrationThis yielded off-white powdery solid which was filtered
  4. washwashed with acetone (2×10 mL)
  5. customdried
  6. customto yield the product

출처 및 근거

ORD 기록
ord-6b36288fdd60451b99de7292bb93f010
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318934B2

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