Diethyl Ether → Ethyl 2-(3-fluorophenoxy)acetate
반응식
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].CCOCC>CN(C=O)C>[CH2:20]([O:19][C:17](=[O:18])[CH2:16][O:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[CH3:21]참가 물질
6
반응 조건
- 온도
- 70 °C
실험 절차
To a solution of 3-fluorophenol (2.24 g, 20.0 mmol) in DMF (40 mL) is added potassium carbonate (3.03 g, 22.0 mmol) and ethyl bromoacetate (2.34 mL, 21.0 mmol), and the mixture is stirred at 70° C. for 18 h. The mixture is cooled to RT, Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled to give 3.2 g of the product 432.
후처리
- temperatureThe mixture is cooled to RT
- washthe mixture is washed with water, brine
- dry with materialdried (MgSO4)
- filtrationfiltered
- customThe filtrate is evaporated
- distillationdistilled
출처 및 근거
- ORD 기록
- ord-99356e1627bb4107842395945d2688b4
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07741493B2
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