Hydrogen chloride-ethyl acetate → 2-[6-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)pyridin-3-yl]-2-hydroxyethyl glycinate dihydrochloride

HRID 1882005노트

반응식

HRID 1882005 반응식
C(OC([NH:8][CH2:9][C:10]([O:12][CH2:13][CH:14]([C:16]1[CH:17]=[N:18][C:19]([C:22]2[NH:23][C:24]([CH:27]([C:35]3[CH:40]=[CH:39][C:38]([S:41]([CH:44]4[CH2:46][CH2:45]4)(=[O:43])=[O:42])=[CH:37][CH:36]=3)[CH2:28][CH:29]3[CH2:34][CH2:33][O:32][CH2:31][CH2:30]3)=[CH:25][CH:26]=2)=[CH:20][CH:21]=1)[OH:15])=[O:11])=O)(C)(C)C.C(OCC)(=O)C.[ClH:53]>C(OCC)(=O)C.C(OCC)C>[ClH:53].[ClH:53].[NH2:8][CH2:9][C:10]([O:12][CH2:13][CH:14]([C:16]1[CH:17]=[N:18][C:19]([C:22]2[NH:23][C:24]([CH:27]([C:35]3[CH:40]=[CH:39][C:38]([S:41]([CH:44]4[CH2:46][CH2:45]4)(=[O:42])=[O:43])=[CH:37][CH:36]=3)[CH2:28][CH:29]3[CH2:30][CH2:31][O:32][CH2:33][CH2:34]3)=[CH:25][CH:26]=2)=[CH:20][CH:21]=1)[OH:15])=[O:11]

참가 물질

5

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593312182-[6-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)pyridin-3-yl]-2-hydroxyethyl N-(tert-butoxycarbonyl)glycinate

생성물 1

HCID 684334432-[6-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)pyridin-3-yl]-2-hydroxyethyl glycinate dihydrochloride수율 41%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-[6-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-1H-pyrrol-2-yl)pyridin-3-yl]-2-hydroxyethyl N-(tert-butoxycarbonyl)glycinate (245 mg) in ethyl acetate (5 mL) was added 4M hydrogen chloride-ethyl acetate solution (210 μL), and the mixture was stirred overnight at room temperature. The reaction mixture was diluted with diethyl ether, and the resulting precipitate was collected by filtration and dried to give the title compound (44.1 mg, yield 41%) as a pale-yellow solid. MS: 554 (MH+).

후처리

  1. filtrationthe resulting precipitate was collected by filtration
  2. customdried

출처 및 근거

ORD 기록
ord-de50073758474aecbabd29448d8da464
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318746B2

반응 노트

불러오는 중…