홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Tetrabutylammonium Fluoride → HCID 59331537, 화합물

HRID 1882013
노트
인쇄 미리보기

반응식

HRID 1882013 반응식
[Si]([O:8][CH:9]([C:11]1[CH:12]=[CH:13][C:14]([C:17]2[NH:18][C:19]([CH:23]([C:31]3[CH:36]=[CH:35][C:34]([S:37]([CH:40]4[CH2:42][CH2:41]4)(=[O:39])=[O:38])=[CH:33][CH:32]=3)[CH2:24][CH:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[CH:20][C:21]=2[CH3:22])=[N:15][CH:16]=1)[CH3:10])(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1.C(OCC)(=O)C>[CH:40]1([S:37]([C:34]2[CH:33]=[CH:32][C:31]([CH:23]([C:19]3[NH:18][C:17]([C:14]4[N:15]=[CH:16][C:11]([CH:9]([OH:8])[CH3:10])=[CH:12][CH:13]=4)=[C:21]([CH3:22])[CH:20]=3)[CH2:24][CH:25]3[CH2:26][CH2:27][O:28][CH2:29][CH2:30]3)=[CH:36][CH:35]=2)(=[O:39])=[O:38])[CH2:42][CH2:41]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 593315955-(1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-3-methyl-1H-pyrrol-2-yl)pyridine

생성물 1

HCID 59331537HCID 59331537, 화합물수율 79%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857
Ethyl Acetate
용매

실험 절차

To a solution (5 mL) of 5-(1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-2-(5-{1-[4-(cyclopropylsulfonyl)phenyl]-2-(tetrahydro-2H-pyran-4-yl)ethyl}-3-methyl-1H-pyrrol-2-yl)pyridine (130 mg) in tetrahydrofuran (5 mL) was added tetrabutylammonium fluoride (1M tetrahydrofuran solution, 256 μL), and the mixture was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate and washed with water. The ethyl acetate layer was washed with saturated aqueous sodium hydrogen carbonate and saturated brine, dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography, and the title compound (83.0 mg, yield 79%) was obtained as a pale-yellow amorphous solid from a fraction eluted with ethyl acetate-hexane (3:1, volume ratio). MS: 495 (MH+).

후처리

  1. washwashed with water
  2. washThe ethyl acetate layer was washed with saturated aqueous sodium hydrogen carbonate and saturated brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c753f7371be24fda94c92454b03d4c2d
출처 데이터셋
uspto-grants-2012_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08318746B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트