4-Nitrobenzaldehyde → 4-Nitro-alpha-(nitromethyl)benzenemethanol

HRID 1882182

반응식

HRID 1882182 반응식
C[SiH2]C1C=CC=CC=1.[N+:9]([C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[O:17])=[CH:14][CH:13]=1)([O-:11])=[O:10].[N+:20]([CH3:23])([O-:22])=[O:21]>C(O)C>[N+:20]([CH2:23][CH:16]([C:15]1[CH:14]=[CH:13][C:12]([N+:9]([O-:11])=[O:10])=[CH:19][CH:18]=1)[OH:17])([O-:22])=[O:21]

참가 물질

5

반응물 3

HCID 5414-NitrobenzaldehydeHCID 6375NitromethaneHCID 69836Methylphenylsilane

생성물 1

HCID 108675844-Nitro-alpha-(nitromethyl)benzenemethanol

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Poly (methylphenylsilane)-supported copper (204 mg, 5 mmol) was added to an ethanol (2.0 ml) solution of p-nitrobenzaldehyde (0.4 mmol) and nitromethane (1.2 mmol), and was stirred at room temperature for 3 hr. The reaction mixture was filtrated, and the filtrate was concentrated, and analyzed by 1H-NMR. Resultantly, 2-nitro-1-(4-nitrophenyl)ethanol was produced at the conversion rate of 95%.

후처리

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-c093846e91df48c09de4ea3bc7897369
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08318967B2

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