참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethyl 2-(4-acetamidophenoxy)acetate | HCID 309738 | — |
| 생성물 | 2-(4-Aminophenoxy)acetic acid hydrochloride | HCID 66811488 | 77.6% |
반응 단계
A mixture (4-acetylamino-phenoxy)-acetic acid ethyl ester 59 (375 grams, 1.582 mmol), in concentrated hydrochloric acid (9.36 liters) was refluxed for 12 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 60 (250 grams, 77.6%) as a wheat colored powder. The melting point was found to be 224-226° C. The structure was confirmed with NMR. IHNMR (D2O) δ 4.68 (s, 2H, OCH2), 3.65 (s, 3H, ester), 7.0 (d, 2H, Ar), 7.30 (d, 2H, Ar.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08318973B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_11 |
|---|
| ORD ID | ord-b5c2c6ad14dd433d84178d49c83c53c9 |
|---|
| 출처 메모 | uspto-grants-2012_11 |
|---|
